Adsorption of anti‐annexin V using dextran sulfate bound cellulose beads
作者： Kimihiro Suzuki , Ayano Satoh , Toshihiko Hidaka , Eiji Takayama , Kouji Kataharada
DOI: 10.1002/1098-1101(2000)15:4<262::AID-JCA8>3.0.CO;2-O
关键词:
摘要: Anti-annexin V (Anx V) antibodies are detected in SLE patients and with habitual fetal loss or preeclampsia. Several case reports have indicated that recurrent abortion based on antiphospholipid syndrome (APS) could be successfully treated immunoadsorption by using dextran sulfate (DS) columns. The purpose of this study is to clarify whether not anti-Anx also adsorbed DS-bound cellulose beads. Sera from V-positive were mixed beads vitro, the titers measured both before after incubation. significantly decreased Anx bound bovine serum albumin-conjugated DS immobilized microtiter plates. results present lend support basic rationale for therapy columns treatment closely associated antibodies.
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