Atrial pressure and postprandial volume regulation in conscious dogs.

摘要: Conscious, chronically instrumented dogs (n=24; left and right atrial catheter, electromagnetic flow probe around the renal artery, carotid loop) were used in 97 expts. to study mechanisms mediating postprandial (pp) excretion of sodium water up at least 180 min after food intake. The kept under standardized conditions maintained on ahigh (14.5 mmol Na/kg b.w./day) or alow (0.5 intake diet (HSI, LSI) which was given once daily morning. In HSI pressure (LAP) increased from a fasting control value 0.2 kPa (2 cm H2O) 0.7 (7 (120–180 pp), 0.0 (0 0.3 (3 H2O). 25% excreted pp. There highly significant positive correlation between pp (U Na V) LAP.U Na V not related increase blood (RBF) glomerular filtration rate (GFR). Fractional 0.6% more than 4% 3.3% 7% anadrenalectomized dog. DOCA did diminishU NA V dogs. LSI dogs, RBF GFR pp, LAP change No substantial inU Na V observed. close ppU Na V supports hypothesis that intrathoracic vascular receptors are involved mediation volume regulation by stimulation still unknown natriuretic operate tubular level presence high mineralocorticoid activity.