Recurrent somatic mutation of FAT1 in multiple human cancers leads to aberrant Wnt activation

作者: Luc G T Morris , Andrew M Kaufman , Yongxing Gong , Deepa Ramaswami , Logan A Walsh

DOI: 10.1038/NG.2538

关键词:

摘要: … genes were regulated by FAT1 in another cancer type, we performed a similar analysis in the TCGA ovarian cancer data set 60 and again found that tumors expressing low amounts of …

参考文章(93)
Ning Ke, Xiaobo Wang, Xiao Xu, Yama A Abassi, None, The xCELLigence system for real-time and label-free monitoring of cell viability. Methods of Molecular Biology. ,vol. 740, pp. 33- 43 ,(2011) , 10.1007/978-1-61779-108-6_6
Steven P. Rockman, Scott A. Currie, Marianne Ciavarella, Elizabeth Vincan, Chris Dow, Robert J. S. Thomas, Wayne A. Phillips, Id2 Is a Target of the β-Catenin/T Cell Factor Pathway in Colon Carcinoma Journal of Biological Chemistry. ,vol. 276, pp. 45113- 45119 ,(2001) , 10.1074/JBC.M107742200
Ken D. Aldape, Russell O. Pieper, Yuichi Hirose, Tomoko Ozawa, Mitchel S. Berger, Yukihiko Sonoda, Martin McMahon, Formation of intracranial tumors by genetically modified human astrocytes defines four pathways critical in the development of human anaplastic astrocytoma. Cancer Research. ,vol. 61, pp. 4956- 4960 ,(2001)
B. Lustig, J. Behrens, The Wnt signaling pathway and its role in tumor development. Journal of Cancer Research and Clinical Oncology. ,vol. 129, pp. 199- 221 ,(2003) , 10.1007/S00432-003-0431-0
Sonja Candidus, Karl-Friedrich Becker, Heinz Höfler, Petra Bischoff, No Evidence for Mutations in the α- and β-Catenin Genes in Human Gastric and Breast Carcinomas Cancer Research. ,vol. 56, pp. 49- 52 ,(1996)
Otto Schmalhofer, Simone Brabletz, Thomas Brabletz, E-cadherin, beta-catenin, and ZEB1 in malignant progression of cancer. Cancer and Metastasis Reviews. ,vol. 28, pp. 151- 166 ,(2009) , 10.1007/S10555-008-9179-Y
Takuji Tanoue, Masatoshi Takeichi, Mammalian Fat1 cadherin regulates actin dynamics and cell–cell contact Journal of Cell Biology. ,vol. 165, pp. 517- 528 ,(2004) , 10.1083/JCB.200403006
K Nakaya, H D Yamagata, N Arita, K-i Nakashiro, M Nose, T Miki, H Hamakawa, Identification of homozygous deletions of tumor suppressor gene FAT in oral cancer using CGH-array. Oncogene. ,vol. 26, pp. 5300- 5308 ,(2007) , 10.1038/SJ.ONC.1210330
Erina Nakamura, Ken-ichi Kozaki, Hitoshi Tsuda, Emina Suzuki, Atiphan Pimkhaokham, Gou Yamamoto, Tarou Irie, Tetsuhiko Tachikawa, Teruo Amagasa, Johji Inazawa, Issei Imoto, Frequent silencing of a putative tumor suppressor gene melatonin receptor 1 A (MTNR1A) in oral squamous-cell carcinoma Cancer Science. ,vol. 99, pp. 1390- 1400 ,(2008) , 10.1111/J.1349-7006.2008.00838.X