Textural, viscoelastic and mucoadhesive properties of pharmaceutical gels composed of cellulose polymers

摘要: Abstract This study examined the mechanical/textural, viscoelastic and mucoadhesive properties of a range aqueous gels composed either hydroxyethylcellulose (HEC) or sodium carboxymethylcellulose (Na CMC). The mechanical/textural each formulation were determined using texture profile analysis. over defined frequency (0.01–1.0 Hz) oscillatory rheometry in conjunction with stainless steel parallel plate geometry. evaluated by measuring tensile force required to overcome gel/mucin adhesive interaction. Both gel hardness compressibility, that affect ease product removal from container spreadability, increased as function increasing polymer concentrations. is attributed effects HEC Na CMC on viscosity. Gel adhesiveness, property related bioadhesion, also concentration reported nature these polymers. Increasing oscillation storage loss moduli yet decreased both dynamic viscosity type tangent (but not CMC) gels. Therefore, following exposure stresses may be expected vivo, will more susceptible than alterations rheological properties. Consequently, it would clinical performance modified greater extent In general, exhibited elastic employed for oscillation. types increased, concentration. strength was dependent time contact mucin conclusion, this has characterised number containing terms their Due its relevance performance, suggested information derived methods usefully combined provide rational basis selection polymers topical drug delivery systems.