Regional lipid peroxidation in rat brain in vitro: possible role of endogenous iron

摘要: Lipoperoxidative capacity of various brain areas aging rats was examined in vitro using the thiobarbituric acid test. Significant regional differences generation lipid peroxides were found freshly prepared homogenates from different incubated under air. Incubation oxygen resulted marked stimulation peroxidation, with highest increases hypothalamus (144%). Addition exogenous Fe2+ and ascorbic peroxidation ranging 10-fold cortex to 20-fold during incubation A linear relationship between endogenous iron content regions their ability produce for all except striatum. Several chelating agents effectively inhibited hyperbaric whereas oxygenfree radical scavengers, as well catalase superoxide dismutase not effective. It is concluded that lipoperoxidative are part governed by local may indicate susceptibility oxidative damage.