Breast Cancer Expression of DAP12 is Associated With Skeletal and Liver Metastases and Poor Survival

摘要: Abstract Background The transmembrane adapter protein, DAP12, transduces activation signals for several arrays of receptors, including human signal-regulatory DAP12-associating lectin-1, triggering receptor expressed on myeloid cells-1, -2, and -3, in natural killer cells, granulocytes, monocytes/macrophages, dendritic cells. macrophage-specific antigen, Cluster Differentiation 163 (CD163), is breast colorectal cancers associated with early cancer recurrence poor prognosis. It was recently shown that fusion between intestinal tumor cells macrophages results nuclear reprogramming hybrid transcripts from both origin. role DAP12 the process not known. This study investigates expression BRC its relation to other macrophage traits clinical progression disease. Materials Methods Immunostaining CD163 performed evaluated paraffin-embedded specimens 132 patients BRC. outcomes were analyzed clinicopathological data. Results positive 66 percent high grade ( P  = .015), liver  = .047) skeletal .067), but lung metastases 1.00). Patients expressing had prognosis, higher rates .018) .047), shorter survival time .0060). Conclusion We suggest facilitate metastatic might promote homing bone tissues.