Neurotoxic effects of dichloroacetylene.

摘要: In inhalation tests involving lethal as well sublethal doses of dichloroacetylene (DCA) (126, 202 and 307 ppm/1 h; 17 ppm/6 h) its neurotoxic effect was examined in rabbits by means histologic neurofunctional methods. Histologic examination revealed chromatolysis, disintegration Nissl bodies, cell shrinkage proportion to the employed nuclei unpaired brain stem, sensory cortical regions especially cranial nerve nuclei. The trigeminal nucleus involved most severely, followed decreasing intensity facial oculomotor nerves motor nucleus; least changes were observed acoustic nerve. By testing protopathic sensitivity skin it possible for first time produce evidence a loss distribution animal experimentation. neuropathological functional deficits may explain lesions human DCA intoxication; however, these seem be less distinct experimental animals.