Cellulose-based materials as scaffolds for tissue engineering

摘要: Two types of cellulose-based materials, 6-carboxycellulose with 2.1 or 6.6 wt% –COOH groups, were prepared and tested for potential use in tissue engineering. The materials functionalized arginine, i.e. an amino acid a basic side chain, chitosan, order to balance the relatively character oxidized cellulose molecules, seeded vascular smooth muscle cells (VSMC). cell adhesion growth then evaluated directly on also underlying polystyrene culture dishes. Of these two studied groups was more appropriate colonization. this material achieved elongated shape, while they spherical shape other materials. number concentration (per mg protein) contractile proteins alpha-actin SM1 SM2 myosins, markers phenotypic maturation VSMC, significantly higher material. Functionalization arginine chitosan further improved VSMC. Chitosan cells. In comparison control dishes, proliferation our low. This suggests that can be used applications where high activity is not desirable, e.g. VSMC prostheses. Alternatively, might enhanced by another efficient modification, which would require research.