Immunoglobulin G, A and M response to influenza vaccination in different age groups: effects of priming and boosting.

摘要: Fifty volunteers, treated with an inactivated trivalent influenza vaccine containing A/Bangkok/1/79 (H3N2), A/Brazil/11/78 (H1N1) and B/Singapore/222/79 virus, were subdivided according to the estimated first exposure in their lifetime (priming) presence of antibodies against components pre-vaccination sera. The isotypic antibody response (IgG, IgA, IgM) was determined by means capture haemadsorption immunosorbent technique. For all three components, previously seropositive subjects produced IgG- IgA-class more frequently than seronegative persons. Subjects primed one A subtypes showed IgG IgA responses comparison those unprimed (prime-effect). In contrast, IgM occurred only 19 11% primed, but 59 54% subjects, for (H3N2) (H1N1), respectively. incidence titre rises not influenced prevaccination state. However, mean magnitude anti-A (H1N1)-IgM greater seronegative. concepts primary reinfection 'original antigenic sin' are discussed, it is suggested that age and, if possible, serological state prior antigen-exposure should be taken into account when studying after infection or vaccination.