In vitro susceptibility of bovine digital dermatitis associated spirochaetes to antimicrobial agents

摘要: Bovine digital dermatitis (BDD) is an infectious lameness in cattle, which has a large global impact terms of animal welfare and cost. The majority evidence suggests that spirochaetes are the aetiological agent this disease. aim study was to identify susceptibility BDD associated range antimicrobial agents with view potential usage vivo treat widespread cattle A microdilution method adapted determine vitro susceptibilities 19 UK (6 Treponema medium/Treponema vincentii-like, 8 phagedenis-like 5 denticola/Treponema putidum-like) eight relevant antimicrobials. exhibited highest penicillin erythromycin information may now be used aid development efficacious treatments. This also identified spirochaete T167 spectinomycin resistant likely biological basis point mutation 16S rRNA gene. Interestingly, nearly all Brachyspira isolate gene sequences Genbank have substitution, suggesting it responsible for characteristic resistance reported genus.