Randomized clinical trial of tetracycline hydrochloride bandage and paste treatments for resolution of lesions and pain associated with digital dermatitis in dairy cattle.

摘要: Digital dermatitis is an infectious disease that causes lameness in dairy cattle, a primary welfare concern of the industry. One common treatments for this painful hoof through application antibiotic bandage must be removed following treatment. The objectives randomized clinical trial were to determine if topical tetracycline hydrochloride paste would as therapeutically effective treatment digital powdered form held place by bandage, and quantify pain associated with lesions. Two hundred fourteen Holstein cow hooves lesions randomly assigned 1 3 treatments: paste, powder 2 d, or negative (untreated) control. Lesions examined at time periods: 7 d posttreatment 8 12 healing rates. Nociceptive thresholds measured using pressure algometer lesion site. was terms rates, 47.4 57.1% healed posttreatment, respectively. Both more than control, which no initial examination. Mean (±SE) nociceptive active, healing, differed, limb-withdrawal response occurring 7.45 (±0.67) kg, 12.84 (±1.85) censored 25 kg (maximum value algometer) force applied, However, active not consistently pain, maximum tolerated when applied 19% lesions, perhaps due variability stoicism between individual cattle changes during progression infection. In conclusion, eliminating need removal application. can both stages, suggesting husbandry interventions mitigation.