Synthesis of l-idaro-1,4-lactone, an inhibitor of α-l-idosiduronase
作者： J. Kenneth Herd , William R. Mayberry , Robert L. Snell
DOI: 10.1016/S0008-6215(00)80972-6
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摘要: Abstract l -Idaro-1,4-lactone was synthesized by two different, published methods: (1) epimerization of monopotassium d -glucarate refluxing in aqueous barium hydroxide, and (2) oxidation -iditol heating dilute nitric acid. The lactone, formed heat dehydration from solution at low pH, purified paper chromatography, quantitated gas-liquid chromatography using inositol as the internal standard. monolactone inhibited human, seminal-fluid α- -idosiduronase activity, with either phenyl or 4-methylumbelliferyl -idosiduronic acid substrate, to same degree -glucaro-1,4-lactone inhibits -glucosiduronase.
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