How to draw kinetic barrier diagrams for enzyme-catalysed reactions.

摘要: A modified way to construct kinetic barrier diagrams is presented. Although the diagram superficially resembles a free-energy profile, it independent of any conception derived from transition-state theory. Some simple calculations referring lactate dehydrogenase turnover reaction at equilibrium demonstrate self-consistency and its direct relevance results numerical simulations detailed course enzyme-catalysed reactions.