Synthesis and scavenging role of furan fatty acids
作者： R. A. S. Lemke , A. C. Peterson , E. C. Ziegelhoffer , M. S. Westphall , H. Tjellstrom
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摘要: Fatty acids play important functional and protective roles in living systems. This paper reports on the synthesis of a previously unidentified 19 carbon furan-containing fatty acid, 10,13-epoxy-11-methyl-octadecadienoate (9-(3-methyl-5-pentylfuran-2-yl)nonanoic acid) (19Fu-FA), phospholipids from Rhodobacter sphaeroides. We show that 19Fu-FA accumulation is increased cells containing mutations increase transcriptional response this bacterium to singlet oxygen (1O2), reactive species generated by energy transfer one or more light-excited donors molecular oxygen. identify undescribed class S-adenosylmethionine-dependent methylases convert phospholipid 18 cis unsaturated acyl chain methylated trans (19M-UFA). also genes required for O2-dependent conversion 19M-UFA 19Fu-FA. Finally, we presence 1O2 leads turnover 19Fu-Fa vivo. propose like can act as membrane-bound scavenger 1O2, which naturally produced integral membrane enzymes R. sphaeroides photosynthetic apparatus.
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