Genotypes and allele frequencies of angiotensin-converting enzyme (ACE) insertion/deletion polymorphism among Bahraini population with type 2 diabetes mellitus and related diseases.

摘要: Insertion/deletion (I/D) polymorphism, of a 287-bp Alu repetitive sequence in intron 16 the angiotensin-converting enzyme (ACE) gene has been shown to be associated with different types diseases and widely investigated populations ethnic origins. Various reports were published suggesting inter-ethnic variations frequency allelic forms ACE gene. The goal this study was test distribution alleles genotypes polymorphism Bahraini subjects compare results those obtained from other population studies. is an Arabic peninsula high prevalence T2DM hypertension. A total 560 unrelated individuals recruited presence (insertion)/absence (deletion) Alu1 element inside done by PCR-based assays or absence analyzed gel electrophoresis. II, ID, DD showed differences among subjects, D allele significantly (P < 0.05) higher studied group. for are consistent previous studies Arabs, Africans, Caucasians, but differs Japanese Chinese, thus proving variation populations.