Clinical Relevance, Prognostic Potential, and Therapeutic Strategies of Noncoding RNAs in Cancer
作者： Rahul Bhome , Louise House , Katherine Emo , Emre Sayan , Alex Mirnezami
DOI: 10.1016/B978-0-12-811022-5.00023-1
关键词:
摘要: Noncoding RNAs (ncRNAs) are master regulators of the genome, controlling most fundamental cellular processes. Several hundred studies have demonstrated their dysregulation across a range cancer types, and translational follow-on led to development putative ncRNA biomarkers for identification staging cancer. Additionally, mechanistic clearly identified key functions ncRNAs in progression, highlighted actionable pathways be targeted by ncRNA-directed therapies. Consequently, ncRNA-derived therapeutics is now entering later stage clinical trials. In this chapter, we describe classification ncRNAs, biology, potential applications.
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