Mutation of the Nrf2 gene in non-small cell lung cancer.
作者： Yi Hu , Yanfang Ju , Dongmei Lin , Zhikuan Wang , Yurong Huang
DOI: 10.1007/S11033-011-1266-4
关键词:
摘要: Nrf2 (NFE2L2) is a transcription factor belonging to the Cap‘N’Collar subfamily of basic-leucine zipper (bZIP) family factors, which plays significant role in adaptive responses oxidative stress. To investigate relationship between mutation gene and non-small cell lung cancer (NSCLC), this study, we sequenced from total 103 patients with NSCLC corresponding blood samples. It found that there discordance mutations These differences may indicate variants are associated an increased risk for cancer. In addition, smoking status observed play important roles triggering occurrence disorder.
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