Cigarette smoking is strongly associated with mutation of the K-ras gene in patients with primary adenocarcinoma of the lung.

作者: Steven A. Ahrendt , P. Anthony Decker , Enas A. Alawi , Yong-ran Zhu , Montserrat Sanchez-Cespedes

DOI: 10.1002/1097-0142(20010915)92:6<1525::AID-CNCR1478>3.0.CO;2-H

关键词:

摘要: … of cigarette smoking to K-ras gene mutations in patients with primary lung adenocarcinoma. … extend previous observations that smokers with adenocarcinoma of the lung are more likely …

参考文章(25)
R. H. Hruban, T. W. Kensler, D. H.J. Van Weering, J. L. Cameron, S. N. Goodman, A. D.M. Van Mansfeld, K. K. Bose, David C. Allison, G. J.A. Offerhaus, J. L. Bos, K-ras oncogene activation in adenocarcinoma of the human pancreas. A study of 82 carcinomas using a combination of mutant-enriched polymerase chain reaction analysis and allele-specific oligonucleotide hybridization. American Journal of Pathology. ,vol. 143, pp. 545- 554 ,(1993)
Steven A Ahrendt, John T Chow, Stephen C Yang, Li Wu, Mei Jie Zhang, Jin Jen, David Sidransky, None, Alcohol consumption and cigarette smoking increase the frequency of p53 mutations in non-small cell lung cancer. Cancer Research. ,vol. 60, pp. 3155- 3159 ,(2000)
M S Greenblatt, W P Bennett, M Hollstein, C C Harris, Mutations in the p53 Tumor Suppressor Gene: Clues to Cancer Etiology and Molecular Pathogenesis Cancer Research. ,vol. 54, pp. 4855- 4878 ,(1994)
Jin Jen, Steve M Powell, Nickolas Papadopoulos, Kelly J Smith, Stanley R Hamilton, Bert Vogelstein, Kenneth W Kinzler, None, Molecular Determinants of Dysplasia in Colorectal Lesions Cancer Research. ,vol. 54, pp. 5523- 5526 ,(1994)
Steven A Ahrendt, Stephen C Yang, Li Wu, William H Westra, Jin Jen, Joseph A Califano, David Sidransky, None, Comparison of oncogene mutation detection and telomerase activity for the molecular staging of non-small cell lung cancer Clinical Cancer Research. ,vol. 3, pp. 1207- 1214 ,(1997)
Kirsti Husgafvel-Pursiainen, Antti Karjalainen, Annamaria Kannio, Sisko Anttila, Timo Partanen, Anneli Ojajärvi, Harri Vainio, Lung cancer and past occupational exposure to asbestos. Role of p53 and K-ras mutations. American Journal of Respiratory Cell and Molecular Biology. ,vol. 20, pp. 667- 674 ,(1999) , 10.1165/AJRCMB.20.4.3404
Stephen L. Graziano, Gary P. Gamble, Nancy B. Newman, Lynn Z. Abbott, Michelle Rooney, Sulagna Mookherjee, Melissa L. Lamb, Leslie J. Kohman, Bernard J. Poiesz, Prognostic Significance of K-ras Codon 12 Mutations in Patients With Resected Stage I and II Non–Small-Cell Lung Cancer Journal of Clinical Oncology. ,vol. 17, pp. 668- 668 ,(1999) , 10.1200/JCO.1999.17.2.668
Catherine L. Carpenter, Hal Morgenstern, Stephanie J. London, Alcoholic Beverage Consumption and Lung Cancer Risk among Residents of Los Angeles County Journal of Nutrition. ,vol. 128, pp. 694- 700 ,(1998) , 10.1093/JN/128.4.694
William H. Westra, Robbert J. C. Slebos, G. Johan A. Offerhaus, Steven N. Goodman, Siegina G. Evers, Thomas W. Kensler, Frederic B. Askin, Sjoerd Rodenhuis, Ralph H. Hruban, K-ras oncogene activation in lung adenocarcinomas from former smokers. Evidence that K-ras mutations are an early and irreversible event in the development of adenocarcinoma of the lung Cancer. ,vol. 72, pp. 432- 438 ,(1993) , 10.1002/1097-0142(19930715)72:2<432::AID-CNCR2820720219>3.0.CO;2-#
Clifton F. Mountain, Revisions in the International System for Staging Lung Cancer Chest. ,vol. 111, pp. 1710- 1717 ,(1997) , 10.1378/CHEST.111.6.1710