Alcohol consumption and cigarette smoking increase the frequency of p53 mutations in non-small cell lung cancer.

摘要: Epidemiological studies have demonstrated a strong association between tobacco use and lung cancer; however, the genetic targets of these carcinogens role other environmental agents in this process yet to be defined. We examined contribution alcohol cigarette smoking top53 gene mutations patients with non-small cell cancer. Mutations p53 were detected by sequence analysis 105 Patient characteristics significantly associated determined using logistic regression. present 53% (56 105). more common who used than consumed less one drink per day (72 versus 39%; P = 0.003), often smokers nonsmokers (58% 10%, 0.02). (P 0.01) drinkers smoked cigarettes [76% (31 41)], nondrinkers (<1 day) [42% (20 48)] or did not smoke [14% (1 7)]. In conclusion, consumption are both The link exposure raises possibility that may enhance mutagenic effects lung.