Selective targeting of p53 gene mutational hotspots in human cancers by etiologically defined carcinogens.
作者： Alain Puisieux , John Groopman , Mehmet Ozturk , Susan Lim
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摘要: Abstract In lung and liver cancers, p53 mutations are mostly G:C to T:A transversions. This type of mutation is known be induced by benzo( a )pyrene aflatoxin B 1 which associated with the etiology respectively. Using novel assay based on DNA polymerase fingerprint analysis, we identified nucleotides targeted these carcinogens. Thirteen 14 nucleotide residues gene underwent in cancers were )pyrene. Similarly, formed adducts at mutational hotspot specific for cancer. The same (third base codon 249), mutates rarely was not target These vitro observations indicate that hotspots different tumors selected targets specifically etiologically defined environmental
aacrjournals.org参考文章(26)
Stuart H. Yuspa, Miriam C. Poirier, Chemical carcinogenesis: from animal models to molecular models in one decade. Advances in Cancer Research. ,vol. 50, pp. 25- 70 ,(1988) , 10.1016/S0065-230X(08)60434-0
T Mitsudomi, S Piantadosi, M M Nau, D T Curiel, I Chiba, D L Buchhagen, H Koga, T Takahashi, D D'Amico, D Carbone, Mutations in the p53 gene are frequent in primary, resected non-small cell lung cancer. Lung Cancer Study Group. Oncogene. ,vol. 5, pp. 1603- 1610 ,(1990)
E Sage, W A Haseltine, High ratio of alkali-sensitive lesions to total DNA modification induced by benzo(a)pyrene diol epoxide. Journal of Biological Chemistry. ,vol. 259, pp. 11098- 11102 ,(1984) , 10.1016/S0021-9258(18)90627-7
Ettore Appella, Joseph R. Testa, Stephen Ullrich, William P. Bennett, Teresa A. Lehman, Curtis C. Harris, Judith A. Welsh, Rama V. Modali, Joseph W. Romano, Jill Ecker, Robert A. Metcalf, Brenda I. Gerwin, p53 mutations, ras mutations, and p53-heat shock 70 protein complexes in human lung carcinoma cell lines. Cancer Research. ,vol. 51, pp. 4090- 4096 ,(1991)
S A Leadon, M M Snowden, Differential repair of DNA damage in the human metallothionein gene family. Molecular and Cellular Biology. ,vol. 8, pp. 5331- 5338 ,(1988) , 10.1128/MCB.8.12.5331
A. D. D'Andrea, W. A. Haseltine, Modification of DNA by aflatoxin B1 creates alkali-labile lesions in DNA at positions of guanine and adenine Proceedings of the National Academy of Sciences of the United States of America. ,vol. 75, pp. 4120- 4124 ,(1978) , 10.1073/PNAS.75.9.4120
T Takahashi, M. Nau, I Chiba, M. Birrer, R. Rosenberg, M Vinocour, M Levitt, H Pass, A. Gazdar, J. Minna, p53: a frequent target for genetic abnormalities in lung cancer Science. ,vol. 246, pp. 491- 494 ,(1989) , 10.1126/SCIENCE.2554494
B. N. Ames, W. E. Durston, E. Yamasaki, F. D. Lee, Carcinogens are Mutagens: A Simple Test System Combining Liver Homogenates for Activation and Bacteria for Detection Proceedings of the National Academy of Sciences of the United States of America. ,vol. 70, pp. 2281- 2285 ,(1973) , 10.1073/PNAS.70.8.2281
William Clay Brown, Louis J. Romano, Effects of benzo[a]pyrene-DNA adducts on a reconstituted replication system. Biochemistry. ,vol. 30, pp. 1342- 1350 ,(1991) , 10.1021/BI00219A026
Isabel Mellon, Philip C. Hanawalt, Induction of the Escherichia coli lactose operon selectively increases repair of its transcribed DNA strand. Nature. ,vol. 342, pp. 95- 98 ,(1989) , 10.1038/342095A0