Lapatinib: New Directions in HER2 Directed Therapy for Early Stage Breast Cancer

Christopher J. Barnes, Rakesh Kumar, Biology of the epidermal growth factor receptor family. Cancer treatment and research. ,vol. 119, pp. 1- 13 ,(2004) , 10.1007/1-4020-7847-1_1

H. S. Rugo, S. Franco, P. Munster, A. Stopeck, W. Ma, J. Lyandres, S. Lahiri, M. Arbushites, M. Koehler, M. N. Dickler, A phase II evaluation of lapatinib (L) and bevacizumab (B) in HER2+ metastatic breast cancer (MBC) Journal of Clinical Oncology. ,vol. 26, pp. 1042- 1042 ,(2008) , 10.1200/JCO.2008.26.15_SUPPL.1042

J R Zabrecky, T Lam, S J McKenzie, W Carney, The extracellular domain of p185/neu is released from the surface of human breast carcinoma cells, SK-BR-3. Journal of Biological Chemistry. ,vol. 266, pp. 1716- 1720 ,(1991) , 10.1016/S0021-9258(18)52354-1

Wenle Xia, Catherine M Gerard, Leihua Liu, Nathalie M Baudson, Thierry L Ory, Neil L Spector, Combining lapatinib (GW572016), a small molecule inhibitor of ErbB1 and ErbB2 tyrosine kinases, with therapeutic anti-ErbB2 antibodies enhances apoptosis of ErbB2-overexpressing breast cancer cells Oncogene. ,vol. 24, pp. 6213- 6221 ,(2005) , 10.1038/SJ.ONC.1208774

Edith A. Perez, Maria Koehler, Julie Byrne, Alaknanda J. Preston, Erica Rappold, Michael S. Ewer, Cardiac Safety of Lapatinib: Pooled Analysis of 3689 Patients Enrolled in Clinical Trials Mayo Clinic Proceedings. ,vol. 83, pp. 679- 686 ,(2008) , 10.4065/83.6.679

Kuo-Fen Lee, Horst Simon, Hua Chen, Brian Bates, Mien-Chie Hung, Christopher Hauser, Requirement for neuregulin receptor erbB2 in neural and cardiac development Nature. ,vol. 378, pp. 394- 398 ,(1995) , 10.1038/378394A0

Wenle Xia, Robert J Mullin, Barry R Keith, Lei-Hua Liu, Hong Ma, David W Rusnak, Gary Owens, Krystal J Alligood, Neil L Spector, Anti-tumor activity of GW572016: a dual tyrosine kinase inhibitor blocks EGF activation of EGFR/erbB2 and downstream Erk1/2 and AKT pathways Oncogene. ,vol. 21, pp. 6255- 6263 ,(2002) , 10.1038/SJ.ONC.1205794

Mercedes Rincon, Gloria Broadwater, Lyndsay Harris, Abigail Crocker, Donald Weaver, Lynn Dressler, Donald Berry, Linda Sutton, Richard Michaelson, Michael Messino, Jeffrey Kirshner, Gini Fleming, Eric Winer, Clifford Hudis, Stacy Appel, Larry Norton, Hyman Muss, , Interleukin-6, multidrug resistance protein-1 expression and response to paclitaxel in women with metastatic breast cancer: results of cancer and leukemia group B trial 159806. Breast Cancer Research and Treatment. ,vol. 100, pp. 301- 308 ,(2006) , 10.1007/S10549-006-9251-7

C. Ozcelik, B. Erdmann, B. Pilz, N. Wettschureck, S. Britsch, N. Hubner, K. R. Chien, C. Birchmeier, A. N. Garratt, Conditional mutation of the ErbB2(HER2) receptor in cardiomyocytes leads to dilated cardiomyopathy. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 99, pp. 8880- 8885 ,(2002) , 10.1073/PNAS.122249299

Hong Zhou, Yeon-Shil Kim, Aaron Peletier, Wes McCall, H.Shelton Earp, Carolyn I Sartor, Effects of the EGFR/HER2 kinase inhibitor GW572016 on EGFR- and HER2-overexpressing breast cancer cell line proliferation, radiosensitization, and resistance International Journal of Radiation Oncology Biology Physics. ,vol. 58, pp. 344- 352 ,(2004) , 10.1016/J.IJROBP.2003.09.046