Biology of the epidermal growth factor receptor family.
作者： Christopher J. Barnes , Rakesh Kumar
关键词:
摘要: Recent research has strengthened the basis for an intimate role of HER family kinases in a variety cancers. In addition to propagating cytoplasmic signaling initiated by receptor ligands, members can also propagate signals multiple other pathways and may serve as central nodes conveying extracellular signals. Attenuation is developing strategy management human malignancies subject ongoing clinical trials preclinical mechanistic investigations.
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