Clinical profile of clozapine: Adverse reactions and agranulocytosis

摘要: The arrival of clozapine has been one the most significant developments in antipsychotic drug treatment since advent chlorpromazine ushered psychopharmacologic era. However, its utilization significantly limited and complicated by potential to cause adverse effects agranulocytosis particular. It must be emphasized that a side effect profile is many ways distinct from standard typical drugs. Side with are common range benign potentially lethal. include sedation, dizziness, sialorrhea during sleep; serious agranulocytosis, seizures respiratory depression. Although not necessarily preventable, they for part manageable. Even effects, proper knowledge medication's actions, clinical vigilance, prompt intervention can prevent occurrence morbidity mortality as consequence treatment.