Drug-induced agranulocytosis: review of possible mechanisms, and prospects for clozapine studies.

摘要: Although toxicity and inborn errors of metabolism may also be involved, immunological reactions play an important role in the induction drug-induced agranulocytosis. Drug-induced antibodies lead to agranulocytosis by at least three different mechanisms. Immune complexes selectively adhere granulocytes or their immature precursor cells, drug bind as carriers immunogenic finally induce directed granulocyte-specific structures. The use interpretation vitro assays detect drug-dependent against myeloid cells are discussed. These will used a possible mechanism involved clozapine-induced Further studies concern identification genetic risk factors associated with