A modular master on the move: the Tn916 family of mobile genetic elements

摘要: The Tn916 family is a group of mobile genetic elements that are widespread among many commensal and pathogenic bacteria. These found primarily, but not exclusively, in the Firmicutes. They integrated into bacterial genome capable conjugative transfer to new host and, often, intracellular transposition different genomic site - hence their name: 'conjugative transposons', or 'integrative elements'. An increasing variety relatives being reported from bacteria, harbouring genes coding for resistance various antibiotics potential encode other functions, such as lantibiotic immunity. This has an extraordinary ability acquire accessory genes, making them important vectors dissemination traits environmental, clinical also responsible rearrangements, providing considerable raw material on which natural selection can act. Therefore, study this essential better understanding control current rise antibiotic