Oxidative Stress-Induced Molecular and Genetic Mechanisms in Human Health and Diseases

摘要: Oxidative stress is a common denominator in many inflammatory diseases. A number of genetic and molecular factors are known to regulate oxidative by modulating cellular redox imbalance. These events lead biochemical changes within the cells resulting myriad biological phenomena including cell growth, initiation progression inflammation, programmed death, senescence. Reactive oxygen species (ROS) well act as important secondary messengers which gene expression through signal transduction pathways especially MAP kinase NF-κB pathway. Additionally, other cascades also regulated oxidants. alterations several such mutations, mitochondrial stress, NADH/NAD+ ratio that further augment aggravate leading health deterioration disease development. Antioxidants, on hand, part defense system destroying ROS enzymatic nonenzymatic mechanisms. In present chapter, we discuss mechanisms play crucial role human