Control of PDGF-induced reactive oxygen species (ROS) generation and signal transduction in human lens epithelial cells.
作者： Marjorie F. Lou , Marjorie F. Lou , You Zhou , Kate Chao Wei Chen , Wei Zhang
DOI:
关键词: Cell biology 、 Reactive oxygen species 、 Platelet-derived growth factor 、 Cell growth 、 Signal transduction 、 Biology 、 Transfection 、 Phosphatidylinositol 3-Kinases 、 Rac GTP-Binding Proteins 、 Platelet-derived growth factor receptor
摘要: Purpose The mitogenic action of PDGF has been shown to associate with reactive oxygen species (ROS) generation, but the mechanism leading ROS production and subsequent cell proliferation is not clear. We investigated upstream membrane-bound target proteins involved in PDGF-stimulated signal transduction human lens epithelial (HLE B3), using specific inhibitors transfected cells.
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