Prevention of Posterior Capsular Opacification through Aldose Reductase Inhibition

作者: Umesh C. S. Yadav , Farshid Ighani-Hosseinabad , Frederik J. G. M. van Kuijk , Satish K. Srivastava , Kota V. Ramana

DOI: 10.1167/IOVS.08-2322

关键词: Aldehyde ReductaseImmunoenzyme techniquesOrgan Culture TechniqueCapsular bagCapsulorhexisAldose reductasePosterior capsular opacificationOphthalmologyBeta-CrystallinMolecular biologyBiology

摘要: Purpose The purpose of this study was to evaluate the effect aldose reductase (AR) inhibition on Posterior capsular opacification (PCO) using pig eye bag model.

参考文章(48)
E Shirasawa, T Akaishi, K Nishi, O Nishi, Detection of cell adhesion molecules in lens epithelial cells of human cataracts. Investigative Ophthalmology & Visual Science. ,vol. 38, pp. 579- 585 ,(1997)
Anna Cerra, Kylie J Mansfield, Coral G Chamberlain, FGF-2 counteracts loss of TGFbeta affected cells from rat lens explants: implications for PCO (after cataract). Molecular Vision. ,vol. 10, pp. 521- 532 ,(2004)
Angela M. Hales, John W. McAvoy, Coral G. Chamberlain, Cataract induction in lenses cultured with transforming growth factor-beta Investigative Ophthalmology & Visual Science. ,vol. 36, pp. 1709- 1713 ,(1995)
Marjorie F. Lou, Marjorie F. Lou, You Zhou, Kate Chao Wei Chen, Wei Zhang, Wei Zhang, Control of PDGF-induced reactive oxygen species (ROS) generation and signal transduction in human lens epithelial cells. Molecular Vision. ,vol. 13, pp. 374- 387 ,(2007)
Heather L. Chandler, Curtis A. Barden, Carmen M.H. Colitz, Ping Lu, Donna F. Kusewitt, Prevention of posterior capsular opacification through cyclooxygenase-2 inhibition. Molecular Vision. ,vol. 13, pp. 677- 691 ,(2007)
Choun-Ki Joo, Eunjoo H. Lee, Role of Transforming Growth Factor-β in Transdifferentiation and Fibrosis of Lens Epithelial Cells Investigative Ophthalmology & Visual Science. ,vol. 40, pp. 2025- 2032 ,(1999)
Suresh K Pandey, David J Apple, Liliana Werner, Anthony J Maloof, E MBiomed, E John Milverton, None, Posterior Capsule Opacification : A Review of the Aetiopathogenesis, Experimental and Clinical Studies and Factors for Prevention Indian Journal of Ophthalmology. ,vol. 52, pp. 99- 112 ,(2004)
John R. Reddan, I. Michael Wormstone, Julia M. Marcantonio, Shigeo Tamiya, Hepatocyte growth factor function and c-Met expression in human lens epithelial cells. Investigative Ophthalmology & Visual Science. ,vol. 41, pp. 4216- 4222 ,(2000)
Angela M. Hales, John W. McAvoy, Coral G. Chamberlain, Jie Liu, Induction of cataract-like changes in rat lens epithelial explants by transforming growth factor beta. Investigative Ophthalmology & Visual Science. ,vol. 35, pp. 388- 401 ,(1994)