A pharmacologic examination of receptors mediating serotonin-induced bronchoconstriction in the anesthetized guinea pig.

摘要: The receptors involved in the bronchoconstriction evoked vivo by intravenous administration to anesthetized guinea pig of serotonin and serotonin-related agonists have been examined this study. Animals were pretreated with indomethacin (+/-)-propranolol inhibit cyclooxygenase beta adrenergic receptors, respectively, pulmonary parameters obtained a Buxco mechanics computer. Dose-dependent increases resistance decreases dynamic lung compliance produced serotonin, 2-methyl-serotonin, 5-methoxy-tryptamine, alpha-methyl-serotonin, 5-carboxamidotryptamine, m-trifluoromethylphenylpiperazine (TFMPP). Responses all except selective 5-hydroxytryptamine3 (5-HT3) agonist, antagonized 5-HT2 antagonists, LY53857 ketanserin. Zaclopride, 1 10 mg/kg, 5-HT3 antagonist, blocked responses 2-methyl-serotonin. A maximally effective dose (1 mg/kg) larger shifts dose-response curves 5-methoxytryptamine alpha-methyl-serotonin than did ketanserin mg/kg). Thiorphan, an inhibitor neutral endopeptidase, potentiated 2-methyl-serotonin and, when studied presence LY53857, also TFMPP. After thiorphan but not or TFMPP, zaclopride. Capsaicin pretreatment animals resulted rightward alpha-methyl-serotonin. Potentiation antagonism zaclopride still evident after capsaicin pretreatment.(ABSTRACT TRUNCATED AT 250 WORDS)