Acidosis-Induced Dysfunction of Cortical GABAergic Neurons through Astrocyte-Related Excitotoxicity.

作者: Li Huang , Shidi Zhao , Wei Lu , Sudong Guan , Yan Zhu

DOI: 10.1371/JOURNAL.PONE.0140324

关键词:

摘要: Background Acidosis impairs cognitions and behaviors presumably by acidification-induced changes in neuronal metabolism. Cortical GABAergic neurons are vulnerable to pathological factors their injury leads brain dysfunction. How acidosis induces neuron remains elusive. As the glia cells interact each other, we intend examine role of astrocytes acidosis-induced injury.

参考文章(69)
A. Tizianello, G. De Ferrari, G. Gurreri, N. Acquarone, Effects of metabolic alkalosis, metabolic acidosis and uraemia on whole-body intracellular pH in man. Clinical Science. ,vol. 52, pp. 125- 135 ,(1977) , 10.1042/CS0520125
Oliver S. Kempski, C. Volk, Neuron-Glial Interaction During Injury and Edema of the CNS Acta Neurochirurgica. ,vol. 60, pp. 7- 11 ,(1994) , 10.1007/978-3-7091-9334-1_2
Paola Bezzi, Maria Domercq, Sabino Vesce, Andrea Volterra, Neuron-astrocyte cross-talk during synaptic transmission: physiological and neuropathological implications Glial cell function. ,vol. 132, pp. 255- 265 ,(2001) , 10.1016/S0079-6123(01)32081-2
Neuron-specific mechanisms for epilepsy self-termination Molecular & Cellular Epilepsy. ,vol. 3, ,(2015) , 10.14800/MCE.716
Bruce E. McKay, Ray W. Turner, Physiological and morphological development of the rat cerebellar Purkinje cell. The Journal of Physiology. ,vol. 567, pp. 829- 850 ,(2005) , 10.1113/JPHYSIOL.2005.089383
Justin A. Beller, Gene G. Gurkoff, Robert F. Berman, Bruce G. Lyeth, Pharmacological enhancement of glutamate transport reduces excitotoxicity in vitro. Restorative Neurology and Neuroscience. ,vol. 29, pp. 331- 346 ,(2011) , 10.3233/RNN-2011-603
Claude B Klee, Anthony R Means, Keeping up with calcium EMBO Reports. ,vol. 3, pp. 823- 827 ,(2002) , 10.1093/EMBO-REPORTS/KVF182
Dangui Wang, Jun Zhao, Zilong Gao, Na Chen, Bo Wen, Wei Lu, Zhuofan Lei, Changfeng Chen, Yahui Liu, Jing Feng, Jin-Hui Wang, Neurons in the barrel cortex turn into processing whisker and odor signals: a cellular mechanism for the storage and retrieval of associative signals. Frontiers in Cellular Neuroscience. ,vol. 9, pp. 320- 320 ,(2015) , 10.3389/FNCEL.2015.00320
Wei-Zhen Wang, Xiang-Ping Chu, Ming-Hua Li, Joshua Seeds, Roger P. Simon, Zhi-Gang Xiong, Modulation of acid-sensing ion channel currents, acid-induced increase of intracellular Ca2+, and acidosis-mediated neuronal injury by intracellular pH. Journal of Biological Chemistry. ,vol. 281, pp. 29369- 29378 ,(2006) , 10.1074/JBC.M605122200
Dwight E Bergles, Craig E Jahr, Synaptic Activation of Glutamate Transporters in Hippocampal Astrocytes Neuron. ,vol. 19, pp. 1297- 1308 ,(1997) , 10.1016/S0896-6273(00)80420-1