Hypotonic versus isotonic maintenance fluids in critically ill children: a multicenter prospective randomized study.

摘要: Aim:  Study the influence of hypotonic (HT) and isotonic (IT) maintenance fluids in incidence dysnatraemias critically ill children. Methods:  Prospective, randomized study conducted three paediatric intensive care units (PICU). One hundred twenty-five children requiring fluid therapy were included: 62 received HT (50–70 mmol/L tonicity) 63 IT (156 mmol/L tonicity). Age, weight, cause admission, sodium intake, diuresis collected. Blood electrolytes measured on 12 24 h later. Results:  levels at 12 h 133.7 ± 2.7 mmol/L group vs. 136.8 ± 3.5 mmol/L (p = 0.001). Adjusted for age, weight level PICU blood values patients receiving decrease by 3.22 mmol/L (CI: 4.29/2.15)(p = 0.000). hyponatraemia increased risk 5.8-fold 2.4–14.0) during period (p = 0.000). Conclusions:  Hypotonic increase because they normonatraemic patients. do not should be considered as standard fluids.