Hippocampal volume reduction and autobiographical memory deficits in chronic schizophrenia.
作者： Christina Josefa Herold , Marc Montgomery Lässer , Lena Anna Schmid , Ulrich Seidl , Li Kong
DOI: 10.1016/J.PSCYCHRESNS.2012.04.002
关键词:
摘要: Although autobiographical memory (AM) deficits and hippocampal changes are frequently found in schizophrenia, their actual association remained yet to be established. AM performance volume were examined 33 older, chronic schizophrenic patients 21 healthy volunteers matched for age, gender education. Psychopathological symptoms additional neuropsychological parameters assessed by using appropriate rating scales; magnetic resonance imaging (MRI) 3-T data analyzed via an automated region-of-interest procedure. When compared with the control subjects, showed significantly decreased left anterior posterior volumes. Episodic but not semantic was lower than controls. Both episodic correlated of hippocampus patient group. In contrast, verbal memory, working remote observed did relate volume. Our findings indicate that schizophrenia associated reductions underline importance this pathology schizophrenia.
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