High-voltage galvanic stimulation on wound healing in guinea pigs: Longer-term effects

摘要: Abstract The purpose of this investigation was to determine the effects high-voltage stimulation (HVS) on wound tensile strength properties and closure (histology). Eighteen mature guinea pigs with full-thickness incisions were treated HVS for 45 minutes daily 2 weeks; 9 animals studied after 14 days treatment remaining weeks later. Five (10 wounds) served as controls at each time period. After or 4 weeks, untreated skin harvested, tested failure, prepared histological examination. Two-week—treated control wounds had comparable values peak force elongation, energy absorbed failure. Epithelialization more advanced in ( p = .068) toward stronger 4-week—treated (maximum load failure), but no differences observed between groups elongation Dermal healing appeared be 30 days. Although failure almost 500g higher than 700g mean data highly variable, so hypothesis that augments could not accepted. It is difficult, however, assign clinical significance findings.