Glucosamine-containing supplement improves locomotor functions in subjects with knee pain: a randomized, double-blind, placebo-controlled study.

摘要: BACKGROUND The aim of this study was to investigate the ability a glucosamine-containing supplement improve locomotor functions in subjects with knee pain. METHODS A randomized, double-blind, placebo-controlled, parallel-group comparative conducted for 16 weeks 100 Japanese (age, 51.8±0.8 years) Subjects were randomly assigned one two supplements containing 1) 1,200 mg glucosamine hydrochloride, 60 chondroitin sulfate, 45 type II collagen peptides, 90 quercetin glycosides, 10 imidazole and 5 μg vitamin D per day (GCQID group, n=50) or 2) placebo (placebo n=50). Knee Osteoarthritis Measure, visual analog scale score, normal walking speed, knee-extensor strength measured evaluate effects on knee-joint functions. RESULTS In eligible efficacy assessment, there no significant group × time interaction, improvements both groups, but difference between groups. mild-to-severe pain at baseline, week 8 (104.6±5.0% body weight vs 92.3±5.5% weight, P=0.030) change speed (0.11±0.03 m/s 0.05±0.02 m/s, P=0.038) significantly greater GCQID than group. Further subgroup analysis based Kellgren-Lawrence (K-L) grade showed that (1.36±0.05 1.21±0.02 P<0.05) K-L I. No adverse effect treatment identified safety assessment. CONCLUSION pain, supplementation effective relieving improving