Chloral hydrate, chloral hydrate--promethazine and chloral hydrate -hydroxyzine efficacy in electroencephalography sedation.

摘要: To compare efficacy and safety of chloral hydrate (CH), promethazine (CH + P) hydroxyzine H) in electroencephalography (EEG) sedation. In a parallel single-blinded randomized clinical trial, ninety 1–7 y-old uncooperative kids who were referred to Pediatric Neurology Clinic Shahid Sadoughi University, Yazd, Iran from April through August 2012, randomly assigned receive 40 mg/kg or 1 mg/kg 2 mg/kg hydroxyzine. The primary endpoint was sufficient sedation (obtaining four Ramsay score) successful completion EEG. Secondary adverse events. Thirty nine girls (43.3 %) 51 boys (56.7 %) with mean age 3.34 ± 1.47 y assessed. Sufficient EEG achieved 70 % (N = 21) group, 83.3 % (N = 25) CH H group 96.7 % (N = 29) P (p = 0.02). Mild events including vomiting [16.7 % (N = 5) CH, 6.7 % (N = 2) P, H], agitation 3.3 % (N = 1) mild transient hypotension occurred. Safety these three regimens not statistically significant different (p = 0.14). Combination hydrate—antihistamines can be used as the most effective safe regimen drug induced sleep kids.