New Treatment Approaches on the Horizon for Spastic Hemiparesis

摘要: Abstract This article presents 2 recent articles that propose novel interventions for treating spastic hemiparesis by changing biological infrastructure. In 18 patients with unilateral arm paralysis due to chronic cerebral injury greater than 5 years’ duration, Zheng et al transferred the C7 nerve from nonparalyzed side of was paralyzed. Over a follow-up period 12 months, they found improvement in function and reduction spasticity compared rehabilitation alone. Using functional magnetic resonance imaging, also evidence physiological connectivity between ipsilateral hemisphere paralyzed hand. second article, Raghavan examine concept stiffness, common symptom hemiparesis, as physical change infrastructure muscle. Raghavan’s non-neural hyaluronan hypothesis postulates an accumulation within muscles promotes development muscle stiffness upper motor neuron syndrome (UMNS). case series 20 report limb intramuscular injections hyaluronidase increased passive active joint movement reduced stiffness. Interventions UMNS is paradigm on horizon bears watching.