Effects of lead and lead–melatonin exposure on protein and gene expression of metal transporters, proteins and the copper/zinc ratio in rats

摘要: Human lead (Pb) exposure induces many adverse health effects, including some related to accumulation in organs. Although bio-distribution the body has been described, molecular mechanism underlying distribution and excretion is not well understood. The transport of essential toxic metals principally mediated by proteins. How affects expression metal transporter proteins principal excretory organs, i.e., liver kidney, unknown. Considering that co-administration melatonin reduces effects levels blood vivo, we examined how affect gene protein (ZIP8, ZIP14, CTR1 DMT1) these Rats were exposed intraperitoneally or lead-melatonin. Our results show Pb changes ZIP8, ZIP14 CTR1. Alterations copper/zinc ratio found blood, kidney likely changes. With DMT1 (gene protein), a positive correlation was with kidney. Co-administration reduced lead-induced through an unknown mechanism. This effect relates function our suggest contributes These data further elucidate on Cu Zn animals.