Turnover of Total Carbon Dioxide in the Aqueous Humors and the Effect Thereon of Acetazolamide

摘要: The rate of turnover free carbon dioxide and bicarbonate ion (total dioxide) in the anterior chamber eye rabbit has been estimated to be about 4% per minute.1 separate rates several components system were taken into account making calculation, but no allowance was made for possible accelerating effect on due conversion ion. Moreover, calculated value also depended upon validity assumption that difference pH between aqueous humor plasma before after giving acetazolamide (Diamox) remained constant, drug had diffusion either or ion, flow reduced one-half by acetazolamide. Since these assumptions may not exact, must regarded as an approximation. Unfortunately, method employed estimating applicable estimation posterior chamber, preliminary experiments employing labeled with Cu did indicate the* very rapid compared other substances. It thought a more detailed study total C02 would lead greater insight some fundame tal processes involved production whole possibly a' better understanding how w intraocular pressure is maintained ^ trolled. Furthermore, it known aC azolamide related compounds affect <" parameters aqueO" dynamics, consequence which lowering reduction concentration W CO2 humors. Accordii'i seemed worth while investigate only nor11 animals those given this dn* Methods