Immunization with α-galactosylceramide polarizes CD1-reactive NK T cells towards Th2 cytokine synthesis
作者： Nicolas Burdin , Laurent Brossay , Mitchell Kronenberg
DOI: 10.1002/(SICI)1521-4141(199906)29:06<2014::AID-IMMU2014>3.0.CO;2-G
关键词:
摘要: We have compared the immune responses of mice immunized either with alpha-galactosylceramide (alpha-GalCer), capable eliciting a CD1-metiated stimulation V alpha14+ NK T cells, or lipoarabinomannan (LAM), glycophospholipid derived from mycobacteria which is known to be presented by CD1b in humans. Within 24 h, alpha-GalCer induces burst IFN-gamma secretion vivo, and recall antigen vitro leads synthesis IL-4 IL-10 addition IFN-gamma. Associated this vivo cytokine release polyclonal activation splenic B cells. CD1-reactive lymphocytes mediate these events, because none them are observed alpha-GalCer-immunized CD1-/- mice. LAM immunization fails promote similar early vivo. Repeated exposure cells secrete but dramatically reduced levels Such bias balance triggered stimulated multiple doses suggests that compound might useful induction Th2 prevention chronic inflammatory conditions mediated Th1 cytokines.
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