An Integrated Approach to Uncover Drivers of Cancer

作者: Uri David Akavia , Oren Litvin , Jessica Kim , Felix Sanchez-Garcia , Dylan Kotliar

DOI: 10.1016/J.CELL.2010.11.013

关键词:

摘要: … Unique to our approach, each driver is associated with a gene module, which is assumed to be altered by the driver. We sometimes gain insight into the likely role of a candidate driver …

参考文章(126)
Daniel Pinkel, Richard Segraves, Damir Sudar, Steven Clark, Ian Poole, David Kowbel, Colin Collins, Wen-Lin Kuo, Chira Chen, Ye Zhai, Shanaz H. Dairkee, Britt-marie Ljung, Joe W. Gray, Donna G. Albertson, High resolution analysis of DNA copy number variation using comparative genomic hybridization to microarrays Nature Genetics. ,vol. 20, pp. 207- 211 ,(1998) , 10.1038/2524
Tamio Suzuki, Wei Li, Qing Zhang, Amna Karim, Edward K. Novak, Elena V. Sviderskaya, Simon P. Hill, Dorothy C. Bennett, Alex V. Levin, H. Karel Nieuwenhuis, Chin-To Fong, Claudio Castellan, Bianca Miterski, Richard T. Swank, Richard A. Spritz, Hermansky-Pudlak syndrome is caused by mutations in HPS4 , the human homolog of the mouse light-ear gene Nature Genetics. ,vol. 30, pp. 321- 324 ,(2002) , 10.1038/NG835
Yukiko Ueda, Ann Richmond, NF‐κB activation in melanoma Pigment Cell Research. ,vol. 19, pp. 112- 124 ,(2006) , 10.1111/J.1600-0749.2006.00304.X
D P Satijn, D J Olson, J van der Vlag, K M Hamer, C Lambrechts, H Masselink, M J Gunster, R G Sewalt, R van Driel, A P Otte, Interference with the Expression of a Novel Human Polycomb Protein, hPc2, Results in Cellular Transformation and Apoptosis Molecular and Cellular Biology. ,vol. 17, pp. 6076- 6086 ,(1997) , 10.1128/MCB.17.10.6076
Kai Wang, Masumichi Saito, Brygida C Bisikirska, Mariano J Alvarez, Wei Keat Lim, Presha Rajbhandari, Qiong Shen, Ilya Nemenman, Katia Basso, Adam A Margolin, Ulf Klein, Riccardo Dalla-Favera, Andrea Califano, Genome-wide identification of post-translational modulators of transcription factor activity in human B cells Nature Biotechnology. ,vol. 27, pp. 829- 837 ,(2009) , 10.1038/NBT.1563
Javier Rangel, Mehdi Nosrati, Stanley P. L. Leong, Chris Haqq, James R. Miller, Richard W. Sagebiel, Mohammed Kashani-Sabet, Novel role for RGS1 in melanoma progression. The American Journal of Surgical Pathology. ,vol. 32, pp. 1207- 1212 ,(2008) , 10.1097/PAS.0B013E31816FD53C
Jinyan Du, Hans R. Widlund, Martin A. Horstmann, Sridhar Ramaswamy, Ken Ross, Wade E. Huber, Emi K. Nishimura, Todd R. Golub, David E. Fisher, Critical role of CDK2 for melanoma growth linked to its melanocyte-specific transcriptional regulation by MITF Cancer Cell. ,vol. 6, pp. 565- 576 ,(2004) , 10.1016/J.CCR.2004.10.014
Tomoo Shiba, Hiroyuki Takatsu, Terukazu Nogi, Naohiro Matsugaki, Masato Kawasaki, Noriyuki Igarashi, Mamoru Suzuki, Ryuichi Kato, Thomas Earnest, Kazuhisa Nakayama, Soichi Wakatsuki, Structural basis for recognition of acidic-cluster dileucine sequence by GGA1 Nature. ,vol. 415, pp. 937- 941 ,(2002) , 10.1038/415937A