Detailed mapping of prostate carcinoma foci: Biopsy strategy implications

摘要: BACKGROUND Prostate carcinoma exhibits considerable anatomic heterogeneity. Detailed characterization of prostate distribution could lead to improved detection procedures and biopsy strategies. We mapped all 607 tumor foci from 180 serially sectioned whole mount radical prostatectomy specimens used a computer algorithm plot summarize the these foci. investigated whether specimen clinical variables predicted differences in distribution. METHODS The volume location each focus were determined digitized. A computer-based was fit digitized paradigm prostate. Pseudo-color summary plots then computed for selected cases. RESULTS Of specimens, 149 (83%) had more than one cancer focus. Most (448 foci, 74%) peripheral zone (PZ). PZ near apex significant midline component. Toward base, diverged laterally. Only 3 (2%) contained solely transition (TZ). Total TZ ≤ 0.5 cm3 55% (52 94) patients. Computer patients with T1c classification (UICC/AJCC) Gleason score 6 greater proportions tumor. CONCLUSIONS Almost occurred The small most may explain ineffectiveness biopsies detect additional cancers during screening. Further, our results suggested that be effective if laterally directed samples are obtained nearer base apical medially. Cancer 2000;89:1800–9. © 2000 American Society.