Intensity-Modulated Radiotherapy for Prostate Cancer Implementing Molecular Imaging with 18F-Choline PET-CT to Define a Simultaneous Integrated Boost
作者： Michael Pinkawa , Richard Holy , Marc D. Piroth , Jens Klotz , Sandra Nussen
DOI: 10.1007/S00066-010-2122-5
关键词: Rectum 、 Medicine 、 Radiology 、 Prostate cancer 、 Radiation treatment planning 、 Hazard ratio 、 Radiation therapy 、 Nuclear medicine 、 Prostate 、 Standardized uptake value 、 PET-CT 、 Oncology 、 Radiology Nuclear Medicine and imaging
摘要: To report the own experience with 66 patients who received 18F-choline PET-CT (positron emission tomography-computed tomography) for treatment planning. Image acquisition followed 1 h after injection of 178–355 MBq 18F-choline. An intraprostatic lesion (GTVPET [gross tumor volume]) was defined by a tumor-to-background SUV (standard uptake value) ratio > 2. A dose 76 Gy prescribed to prostate in 2-Gy fractions, simultaneous integrated boost up 80 Gy. volume could not be single patient. One, two and three or more lesions were found 36 (55%), 22 (33%) seven (11%). The lobe(s) positive biopsy correlated GTVPET same lobe 63 cases (97%). additionally 33 41 lobes (80%) only negative biopsies. GTVPET, SUVmean SUVmax dependent on well-known prognostic risk factors, particularly T-stage Gleason Score. In multivariate analysis, Score 7 resulted as an independent factor 8 cm3 (hazard 5.5; p = 0.02) 5 4.4; 0.04). Neoadjuvant hormonal (NHT) did affect levels. mean EUDs (equivalent uniform doses) rectum bladder (55.9 54.8 Gy) comparable (n 18) treated period without (54.3 55.6 Gy). Treatment planning allows definition nearly all cancer – including NHT considerably affecting organs at risk. levels
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