Anchoring proteins for protein kinase C: a means for isozyme selectivity
作者： Daria Mochly-Rosen , Adrienne S. Gordon
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摘要: Protein kinase C (PKC) isozymes comprise a family of related enzymes. There are only limited differences between these in substrate specificity or sensitivity to activators. However, there multiple within cell mediating isozyme-specific functions. Differential subcellular localization has been proposed explain this specificity. When members the PKC activated by lipid-derived second messengers, they translocate from one compartment another. Isozyme appears be mediated part association each isozyme with specific anchoring proteins. This review will cover proteins involved at sites, domains that mediate protein-protein interaction proteins, and identification peptides interfere promote interactions, thus altering function individual isozymes.
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