Production of sucralose without intermediate isolation of crystalline sucralose-6-ester

作者: Robert E. Walkup , David S. Neiditch , Nicholas M. Vernon , Juan L. Navia

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摘要: There is disclosed a process for producing sucralose from sucralose-6-ester whereby the deacylated directly either prior to or after removal of tertiary amide reaction vehicle neutralized chlorination mixture, produce an aqueous solution plus salts and impurities, which recovered by extraction then preferably purified crystallization.

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Juan L. Navia, Process for synthesizing sucrose derivatives by regioselective reaction Process for synthesizing sucrose derivatives by regioselective reaction.. ,(1989)
Robert E. Walkup, Robert E. Wingard, Nicholas M. Vernon, Selective 6-acylation of sucrose mediated by cyclic adducts of dialkyltin oxides and diols ,(1991)
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