Preoperative chemoradiotherapy in locally advanced rectal cancer: correlation of a gene expression-based response signature with recurrence
作者： Torsten Liersch , Marian Grade , Jochen Gaedcke , Sudhir Varma , Michael J. Difilippantonio
DOI: 10.1016/J.CANCERGENCYTO.2008.11.011
关键词:
摘要: Preoperative chemoradiotherapy is recommended for locally advanced rectal cancer (UICC stage II/III). We recently demonstrated that responsive and nonresponsive tumors showed differential expression levels of 54 genes. In this follow-up study, we investigated the relationship between gene set disease-free (DFS) overall survival (OS). Pretherapeutic biopsies from 30 participants in CAO/ARO/AIO-94 trial German Rectal Cancer Study Group were analyzed using microarrays. Statistical analysis was performed to identify differentially expressed genes recurrent nonrecurrent correlate these changes with disease recurrence outcome. After a median 59 months, seven eight patients nonresponder, one tumor recurred. Response significantly correlated an improved DFS (log rank P=0.028), whereas OS did not differ (P=0.11). Applying class comparison analysis, identified 20 (P<0.001). Analyzing first two principal components previously predict response, observed response signature increased risk recurrence. These data suggest genetic basis local also affects Genes are indicative nonresponse preoperative might be linked
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sci-hub.se 参考文章(47)
T. Liersch, C. Langer, C. Jakob, D. Müller, B.M. Ghadimi, A. Siemer, P.M. Markus, L. Füzesi, H. Becker, Präoperative Diagnostik beim lokal fortgeschrittenen Rektumkarzinom (≥T3 oder N+) Der Chirurg. ,vol. 74, pp. 224- 234 ,(2003) , 10.1007/S00104-002-0609-Z
TNM classification of malignant tumours Published in <b>2010</b> in Chichester, West Sussex, UK ;Hoboken, NJ by Wiley-Blackwell. ,(1987) , 10.1007/978-3-642-82982-6
P. Quirke, M.F. Dixon, P. Durdey, N.S. Williams, Local recurrence of rectal adenocarcinoma due to inadequate surgical resection. Histopathological study of lateral tumour spread and surgical excision. The Lancet. ,vol. 328, pp. 996- 999 ,(1986) , 10.1016/S0140-6736(86)92612-7
R.J Heald, R.D.H Ryall, Recurrence and survival after total mesorectal excision for rectal cancer. The Lancet. ,vol. 327, pp. 1479- 1482 ,(1986) , 10.1016/S0140-6736(86)91510-2
Suresh K. Rayala, Rakesh Kumar, Sliding p21-activated kinase 1 to nucleus impacts tamoxifen sensitivity. Biomedicine & Pharmacotherapy. ,vol. 61, pp. 408- 411 ,(2007) , 10.1016/J.BIOPHA.2007.05.006
Puri Fortes, Dasa Longman, Susan McCracken, Joanna Y. Ip, Raymond Poot, Iain W. Mattaj, Javier F. Cáceres, Benjamin J. Blencowe, Identification and characterization of RED120: a conserved PWI domain protein with links to splicing and 3'-end formation. FEBS Letters. ,vol. 581, pp. 3087- 3097 ,(2007) , 10.1016/J.FEBSLET.2007.05.066
P. Quirke, M. F. Dixon, The prediction of local recurrence in rectal adenocarcinoma by histopathological examination. International Journal of Colorectal Disease. ,vol. 3, pp. 127- 131 ,(1988) , 10.1007/BF01645318
Antonello D'Arrigo, Claudio Belluco, Alessandro Ambrosi, Maura Digito, Giovanni Esposito, Antonella Bertola, Michele Fabris, Valentina Nofrate, Enzo Mammano, Alberta Leon, Donato Nitti, Mario Lise, Metastatic transcriptional pattern revealed by gene expression profiling in primary colorectal carcinoma. International Journal of Cancer. ,vol. 115, pp. 256- 262 ,(2005) , 10.1002/IJC.20883
Yuko Sugiyama, Buckminster Farrow, Carlos Murillo, Jing Li, Hiroaki Watanabe, Kazuo Sugiyama, B. Mark Evers, Analysis of differential gene expression patterns in colon cancer and cancer stroma using microdissected tissues Gastroenterology. ,vol. 128, pp. 480- 486 ,(2005) , 10.1053/J.GASTRO.2004.11.010
Tong-Tong Zou, Florin M Selaru, Yan Xu, Valentina Shustova, Jing Yin, Yuriko Mori, David Shibata, Fumiaki Sato, Suma Wang, Andreea Olaru, Elena Deacu, Thomas C Liu, John M Abraham, Stephen J Meltzer, Application of cDNA microarrays to generate a molecular taxonomy capable of distinguishing between colon cancer and normal colon. Oncogene. ,vol. 21, pp. 4855- 4862 ,(2002) , 10.1038/SJ.ONC.1205613