Solid phase synthesis and RNA-binding activity of an arginine-containing nucleopeptide
作者： G. N. Roviello , C. Vicidomini , S. Di Gaetano , D. Capasso , D. Musumeci
DOI: 10.1039/C5RA25809J
关键词:
摘要: Here we report the solid phase synthesis and characterization (LC-ESIMS, CD) of a cationic nucleobase-containing α-peptide, composed both L-arginine residues L-lysine-based nucleoamino acids sequentially present in structure. The binding properties this novel basic nucleopeptide towards nucleic were investigated by CD spectroscopy which revealed ability thymine-containing oligomer to bind adenine-containing DNA (dA12) RNA (poly rA) molecules inducing high conformational variations acid structures. Moreover, artificial oligonucleotide inhibited enzymatic activity HIV reverse transcriptase, opening door exploitation antiviral strategies inspired molecular tool.
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