Systemic Chemotherapy in Brain Gliomas

摘要: Gliomas constitute the most common and difficult to treat primary brain tumors, accounting for over 50% of all central nervous system tumors. The glioblastoma is by far frequently occurring malignant glial with a median patient survival 15 months. Current treatment involves maximal surgical resection followed radiotherapy concomitant adjuvant chemotherapy. However, last decade much has changed regarding role chemotherapy in gliomas. This result several trials that reported benefit combination agents incorporation molecular genetic markers as predictors response Herewith we discuss regimens currently used glioma well associated toxicities try provide an insight into future advancements.