Autophagy in cancers including brain tumors: role of MicroRNAs
作者： Mohammad Hossein Pourhanifeh , Maryam Mahjoubin-Tehran , Mohammad Reza Karimzadeh , Hamid Reza Mirzaei , Zahra Sadat Razavi
DOI: 10.1186/S12964-020-00587-W
关键词:
摘要: Autophagy has a crucial role in many cancers, including brain tumors. Several types of endogenous molecules (e.g. microRNAs, AKT, PTEN, p53, EGFR, and NF1) can modulate the process autophagy. Recently miRNAs (small non-coding RNAs) have been found to play vital regulation different cellular molecular processes, such as Deregulation these is associated with development progression pathological conditions, It was that are epigenetic regulators, which influence level proteins coded by targeted mRNAs any modification genetic sequences. revealed various (e.g., miR-7-1-3p, miR-340, miR-17, miR-30a, miR-224-3p, miR-93), autophagy pathways within A deeper understanding underlying targets miRNAs, their function could contribute new treatment methods for patients In this review, we summarize involved regulating Moreover, highlight autophagy-related cancers.
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