Sensitization of cisplatin-resistant ovarian cancer cells by magnetite iron oxide nanoparticles: an in vitro study.
作者： Kurtulus Gokduman
关键词:
摘要: Aim: To investigate potential of magnetite iron oxide nanoparticles (MION) to sensitize cisplatin-resistant ovarian cancer cells cisplatin, which the best found knowledge has not been reported previously. Materials & methods: MION with a diameter approximately 20 nm were synthesized, and characterized using Fourier transform infrared spectroscopy, powder x-ray diffraction particle size analyzer. Results: The synthesized have increased reactive oxygen species levels decreased glutathione in (OVCAR-3 SKOV-3). Using MTT, capsase-3 activity live/dead assays, capability illustrated. Conclusion: Thus, for further investigations, can be considered as potent agent enabling much more effective cisplatin-based therapies cancer.
sci-hub.se 参考文章(66)
N Mohell, J Alfredsson, Å Fransson, M Uustalu, S Byström, J Gullbo, A Hallberg, V J N Bykov, U Björklund, K G Wiman, APR-246 overcomes resistance to cisplatin and doxorubicin in ovarian cancer cells Cell Death and Disease. ,vol. 6, ,(2015) , 10.1038/CDDIS.2015.143
Cristina Espinosa-Diez, Verónica Miguel, Daniela Mennerich, Thomas Kietzmann, Patricia Sánchez-Pérez, Susana Cadenas, Santiago Lamas, Antioxidant responses and cellular adjustments to oxidative stress. Redox biology. ,vol. 6, pp. 183- 197 ,(2015) , 10.1016/J.REDOX.2015.07.008
Jiahui Liu, Zhichong Wang, Increased Oxidative Stress as a Selective Anticancer Therapy Oxidative Medicine and Cellular Longevity. ,vol. 2015, pp. 294303- 294303 ,(2015) , 10.1155/2015/294303
Edward A. Neuwelt, Leslie L. Muldoon, Alexander J. Neuwelt, Ying Jen Jeffrey Wu, Acetaminophen enhances cisplatin- and paclitaxel-mediated cytotoxicity to SKOV3 human ovarian carcinoma. Anticancer Research. ,vol. 33, pp. 2391- 2400 ,(2013)
Ujwal Patil, Shiva Adireddy, Ashvin Jaiswal, Sree Mandava, Benjamin Lee, Douglas Chrisey, In Vitro/In Vivo Toxicity Evaluation and Quantification of Iron Oxide Nanoparticles. International Journal of Molecular Sciences. ,vol. 16, pp. 24417- 24450 ,(2015) , 10.3390/IJMS161024417
Vaishaali Natarajan, Christina L. Wilson, Stephen L. Hayward, Srivatsan Kidambi, Titanium Dioxide Nanoparticles Trigger Loss of Function and Perturbation of Mitochondrial Dynamics in Primary Hepatocytes PLOS ONE. ,vol. 10, pp. e0134541- ,(2015) , 10.1371/JOURNAL.PONE.0134541
Gerald M. COHEN, Caspases: the executioners of apoptosis Biochemical Journal. ,vol. 326, pp. 1- 16 ,(1997) , 10.1042/BJ3260001
Neha Kaushik, Nizam Uddin, Geon Bo Sim, Young June Hong, Ku Youn Baik, Chung Hyeok Kim, Su Jae Lee, Nagendra Kumar Kaushik, Eun Ha Choi, Responses of Solid Tumor Cells in DMEM to Reactive Oxygen Species Generated by Non-Thermal Plasma and Chemically Induced ROS Systems Scientific Reports. ,vol. 5, pp. 8587- 8587 ,(2015) , 10.1038/SREP08587
Mihaela Radu, Maria Munteanu, Sorina Petrache, Andreea Serban, Diana Dinu, Anca Hermenean, Cornelia Sima, Anca Dinischiotu, None, Depletion of intracellular glutathione and increased lipid peroxidation mediate cytotoxicity of hematite nanoparticles in MRC-5 cells. Acta Biochimica Polonica. ,vol. 57, pp. 355- 360 ,(2010) , 10.18388/ABP.2010_2416
Lihua Cheng, Chengmeng Jin, Wen Lv, Qiuping Ding, Xu Han, Developing a Highly Stable PLGA-mPEG Nanoparticle Loaded with Cisplatin for Chemotherapy of Ovarian Cancer PLoS ONE. ,vol. 6, pp. e25433- ,(2011) , 10.1371/JOURNAL.PONE.0025433