Association of KIR genotypes and haplotypes with syphilis in a Chinese Han population.
作者： Y. L. Zhuang , Y. Song , C. Zhu , Y. Zhang , D. Wang
DOI: 10.1111/J.1365-3083.2011.02664.X
关键词:
摘要: Killer immunoglobulin-like receptors (KIRs) can regulate the activation of NK and T cells in response to infection. Syphilis is a sexually transmitted infection caused by Treponema pallidum subspecies spirochete bacterium. The objective this study was explore whether KIR genotypes haplotypes were associated with syphilis Chinese Han population. Polymerase chain reaction sequence-specific primers (PCR–SSP) used identify 190 patients 192 healthy controls. frequency genotype P higher controls than that (P = 0.002), its OR 0.304, while frequencies AE AG those haplotype 17 lower, 0.321, whereas 1 6 A B have distinctive centromeric (Cen) telomeric (Tel) gene content motifs. Tel-B/B (P = 0.024). Based on these findings, it seems individuals AE, or Tel-B/B, are susceptible syphilis, protective from
sci-hub.se 参考文章(34)
Yao JianYi, Zhang WeiDong, Epidemiological characteristics of syphilis in China, 1998-2007. Disease Surveillance. ,vol. 24, pp. 830- 831 ,(2009)
Lisbeth A Guethlein, Clair M Gardiner, Nathalie W Cheng, Dolly Tyan, Neil Thomas Young, Peter Parham, Heather G Shilling, Genetic control of human NK cell repertoire ,(2001)
Daniel S. Korbel, Paul J. Norman, Kirsty C. Newman, Amir Horowitz, Ketevan Gendzekhadze, Peter Parham, Eleanor M. Riley, Killer Ig-Like Receptor (KIR) Genotype Predicts the Capacity of Human KIR-Positive CD56dim NK Cells to Respond to Pathogen-Associated Signals Journal of Immunology. ,vol. 182, pp. 6426- 6434 ,(2009) , 10.4049/JIMMUNOL.0804224
W C van Voorhis, L K Barrett, J M Nasio, F A Plummer, S A Lukehart, Lesions of primary and secondary syphilis contain activated cytolytic T cells. Infection and Immunity. ,vol. 64, pp. 1048- 1050 ,(1996) , 10.1128/IAI.64.3.1048-1050.1996
Wim Jennes, Sonja Verheyden, Christian Demanet, Christiane A. Adjé-Touré, Bea Vuylsteke, John N. Nkengasong, Luc Kestens, Cutting edge: resistance to HIV-1 infection among African female sex workers is associated with inhibitory KIR in the absence of their HLA ligands. Journal of Immunology. ,vol. 177, pp. 6588- 6592 ,(2006) , 10.4049/JIMMUNOL.177.10.6588
Zhiming Lu, Bingchang Zhang, Shijun Chen, Zhongtao Gai, Zhaolei Feng, Xiangdong Liu, Yiqing Liu, Xin Wen, Li Li, Yulian Jiao, Chunyan Ma, Song Shao, Xiangfa Cui, Guojian Chen, Jianfeng Li, Yueran Zhao, Association of KIR Genotypes and Haplotypes with Susceptibility to Chronic Hepatitis B Virus Infection in Chinese Han Population Cellular & Molecular Immunology. ,vol. 5, pp. 457- 463 ,(2008) , 10.1038/CMI.2008.57
Nadia Wauquier, Cindy Padilla, Pierre Becquart, Eric Leroy, Vincent Vieillard, Association of KIR2DS1 and KIR2DS3 with fatal outcome in Ebola virus infection Immunogenetics. ,vol. 62, pp. 767- 771 ,(2010) , 10.1007/S00251-010-0480-X
Markus Uhrberg, Peter Parham, Peter Wernet, Definition of gene content for nine common group B haplotypes of the Caucasoid population: KIR haplotypes contain between seven and eleven KIR genes Immunogenetics. ,vol. 54, pp. 221- 229 ,(2002) , 10.1007/S00251-002-0463-7
John Trowsdale, Roland Barten, Anja Haude, C. Andrew Stewart, Stephan Beck, Michael J. Wilson, The genomic context of natural killer receptor extended gene families Immunological Reviews. ,vol. 181, pp. 20- 38 ,(2001) , 10.1034/J.1600-065X.2001.1810102.X
Yu Suzuki, Yoshiaki Hamamoto, Yumie Ogasawara, Kimi Ishikawa, Yoshiaki Yoshikawa, Takehiko Sasazuki, Masahiko Muto, Genetic polymorphisms of killer cell immunoglobulin-like receptors are associated with susceptibility to psoriasis vulgaris. Journal of Investigative Dermatology. ,vol. 122, pp. 1133- 1136 ,(2004) , 10.1111/J.0022-202X.2004.22517.X